Correlation among Insulin Sensitivity and Serum Indirect Bilirubin Level in Patients Having Obesity
The aim of this study is to discuss the correlation among insulin sensitivity and serum indirect bilirubin level in patients having obesity. The study analyzed 61 obese patients aged 16-70 with a BMI of 28.0 kg/m2 from April 2023 to March 2024. The patients were divided into two groups: those with type 2 diabetes and those without. Insulin sensitivity was assessed using glucose disposal rate and physiological evaluation. The study employed a multivariate logistic regression approach and SPSS version 23.0 for mathematical computations. The individuals were split into two groups: the T2DM group and the control group. The T2DM group had significantly poorer insulin sensitivity (M value) than the control group. There were no statistically significant variations in BMI, FINS, or FC-p between the two groups (p > 0.05). The T2DM group showed no correlations between DBIL and any metabolism variables. IBIL also had a positive association with M value and unfavorably associated with FINS and FC-p. Serum bilirubin levels and metabolism factors did not correlate in the control group. Participants in the T2DM group were addressed with the purpose to better evaluate the association between bilirubin and insulin sensitivity. The results of the multivariate logistic regression evaluation indicate that the probability of insulin resistance decreases with increasing bilirubin levels. There were differences in the associations between insulin sensitivity and various forms of bilirubin. Serum indirect bilirubin may improve insulin sensitivity and function as an antioxidant.
